Ketamine Treatment

A pivotal study on the effectiveness of IV ketamine for psychiatric symptoms is the Berman et al. (2000) study, published in Biological Psychiatry. This double-blind, placebo-controlled trial demonstrated that a single infusion of ketamine produced rapid and substantial reductions in depressive symptoms within hours, compared to the placebo, in patients with major depressive disorder. The study’s groundbreaking findings highlighted ketamine’s potential as a fast-acting antidepressant, particularly for individuals with treatment-resistant depression.